Sullyco wrote:Cuffs, vg's, and wingtip extensions, do not "Kill Drag" .... wheel pants, wing root fairings, etc... kill drag

Fair enough depending on the application, but they do add lift. The VGs on my Cherokee 140 did killl drag, because they allowed a previously stalled portion of the wing to create lift by energizing the airflow in that wing section. The result was to create lift out of a wing area that used to only create drag. So, I call turning drag into lift, killing drag. Furthermore, I did use gap seals to kill drag on the same plane.
You are also missing something I didn't write. In gliders people do all sorts of things to kill drag and improve their aerodynamic situation. These may include taping over gaps, better seals on flight controls, or other parts of the aircraft, even lower drag air venting systems. All these things add up. My point was I have seen this stuff work in both gliders and powered aircraft.
If you can modify to reduce drag or create more lift, it can work very well. Or you can just pay more for gas and use a bigger engne.