Compiling some thoughts from the other thread about the Viking/Honda 110hp auto conversion...
Getting philosophical about purpose built auto vs purpose built aircraft engines, one has to ask what the real objective is. Taking money out of the equation, I think the appeal of most auto conversions is the pursuit of better technology-- EFI, electronic ignition, tighter ring gap and more consistent compressions that are enjoyed by the more even and effective liquid cooling. Technology for the sake of technology isn't inherently better though.
If the pursuit is simplicity and consistent optimization, then true FADEC and the automation of combustion optimization are a huge improvement over the current state of the purpose-built aircraft engine. But really, which is the simpler system? A mechanical carburetor with a few moving parts and a manual mixture control, relying on the pilot's own judgment and interpretation of realtime data from his engine monitor(or the old lean-until-roughness-then-enrichen-a-little trick) --or-- a computerized combustion monitoring system that can make changes at a high frequency interval, always giving you optimum power or efficiency, or both?
It seems that the reliability of the old Conti and Lyc boxers stems mostly from mechanical simplicity, looser tolerances, lots of oil, and a maintenance mentality (conservative) that keeps a keen eye on known trouble areas. We've been using these same engines in one form or another for 70 years, and they are proven. I sometimes sense though that some of the resistance to adopting newer engine technologies is not solely the classic "FAA certifications requirements stifling development," but rather our own sense of conservative tradition, enjoying the easily understandable and comprehendible classic opposed, air-cooled, carbureted, magneto-ignition'd, direct-drive engine.
Electronic ignition provides always perfect timing, and dynamic retard/advance throughout the RPM range. Ignition curves can be remapped depending on the application. Perhaps there is an optimum for swinging a prop at constant RPM, verses the short bursts of power needed in an automotive application? Of course, modern automotive electronic ignitions make you totally dependent on the battery/alternator for ignition. A conventional magneto ignition engine will continue running without input current.
I saw a video on Youtube once of these guys trying to destroy a Toyota R22 4-cylinder engine by draining all the oil and pinning the throttle. It took something like 15 minutes for it to even begin seizing. Yet the story of the oil starved Continental/Lyc always has complete lock-up only a few minutes after loss of oil pressure. What's the disparity there? How can one engine be so resilient and another so delicate? I admit to knowing little about lubrication system design.
Weight, shape, volume, mounting options...many variables. What are the benefits of opposed vs inline cylinder arrangement for a 4-cylinder engine? Seems more obvious for 6 and 8 cylinder engines, but same principle I guess.
Fantasy engines aside (we have threads for vaporware diesels), where would you start if you wanted to aviation-harden a proven engine core but retain the things about modern small bore car engines that eclipse the reliability of the most common aviation classic engines?

I have an airboat with a 350 chev engine and a direct drive prop that I turn right under 3000 rpm and I force the prop disc to change it's alignment and attitude VIOLENTLY and CONSTANTLY and so far have not had it fly apart on me. This engine has nothing for thrust bearings except the little side plates on three of the mains, so there ya go.