Opinions are like certain body parts - everybody's got one ... but it's kinda fun to survey different people's take on what's a pretty important question for those who fly cross country on a regular basis ... like me!
Since most of us live on a non-bazillionaire's budget, let's assume your question is really directed to piston aircraft ... any plane with a turbine is going to be a seven-figure investment which most of us can't swing.
My opinion: I have been pining for some time over my "next airplane" (who isn't?
), which would be Piper (naturally) Seneca II or III-TC. Why?
It's reasonably fast - with a reliable cruise on the order of 185 knots (yeah, other twins, and some singles, fly faster)
It's a Cherokee - meaning it's got very tame flying manners ... it's a lot harder to get into trouble with a Seneca than with, say, a Baron or a C-310.
It's got a very large, wide, comfortable cabin ... meaning little or no claustrophobia for pilot or passengers ... and can cary a load of 6 souls plus bags in reasonable comfort, or 4 souls, lots of bags, and full fuel for a long ride.
The Seneca has a safety advantage over most other light twins - it's got counterrotating engines, meaning it doesn't have a "critical engine". The biggest drawback to light twin safety is having to deal with an outage of the critical engine.
And the Seneca II or III-TCs can fly high in the lower flight levels, over most weather, and they also typically come equipped with anti-icing and/or de-icing equipment, making it a serious IFR platform.
Lastly, the fuel burn on the 220-hp turbo IO-360s is considerably less than what you get with some of the competitive light twins out there.
Prices? You can pick up a Seneca II or III-TC in pretty good condition for low 100's to low 200s (the IIs will be near the lower end of that range, and the IIIs will be near the upper end of that range). So it's affordable for a lot more people than any turbine-powered aircraft, and can be bought for the price of a used Bonanza or Cirrus SR22, neither of which has as big and comfortable cabin, or the security of a backup engine - important if you're crossing mountains or oceans.