I've been up and down the Owens Valley twice in the last two years on my trips to and from Boise and SoCal. I must have always got lucky, because the three times through the Owens Valley, it was nice and smooth for me.
Also, depending your path of flight, day of the week and time of day, I found flying through the Edwards Restricted Airspace simple if your already on VFR Flight Following.
Pictures from my flight from Boise to SoCal (12-08).
Heading south for Bishop. Here I'm about 40nm north of Bishop (KBIH) and the White Mountain range to the left.
Short final for 12 at Bishop, CA.
After fueling up in Bishop, I'm headed south for SoCal.
Here's some pictures from my trip to SoCal one year later (Dec. 2009)
About 25nm of Bishop with the White Mountains to my left
3 6 Delta parked at Bishop. The Sierras in the background.
Honda Motors test facility
Almost to L.A. About to fly over the mountains north of L.A.
Mt. Baldy to the east there.
Santa Ana Mtns in the distance. Almost to Fullerton (KFUL)